Two new studies offer insights into the molecular biology of neuropsychiatric disease

May 24 2024Mount Sinai Health System Working under the umbrella of the PsychENCODE Consortium, the mental health research project established in 2015 by the National Institutes of Health, a team of Mount Sinai scientists has uncovered important new insights into the molecular biology of neuropsychiatric disease through two new studies published in a special issue of Science on Friday, May 24.

Since the launch of PsychENCODE, dozens of scientists from Mount Sinai along with colleagues from 14 other research institutions have identified several hundred new risk genes for mental disorders that include schizophrenia, autism spectrum disorder, and bipolar disorder. That body of work has also revealed critical time windows during brain development when these genes can most influence the disease process.

"While we observed gene change expression within all detected cell types, the majority occurred in neuronal populations and, specifically, more than three-quarters in excitatory neurons, which constitute the bulk of the brain's neurons," says Dr. Roussos, who led the analysis with John Fullard, PhD, Assistant Professor of Psychiatry, and Genetics and Genomic Sciences, at Icahn Mount Sinai. The collaboration included partners from the Eli and Edythe L.

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Two studies offer key insights into the origins and potential treatment of mental health disordersWorking under the umbrella of the PsychENCODE Consortium, the mental health research project established in 2015 by the National Institutes of Health, a team of Mount Sinai scientists has uncovered important new insights into the molecular biology of neuropsychiatric disease through two new studies published in a special issue of Science on May 24.
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