What happens when you stop taking weight-loss drugs?

Weight-suppressant drugs have helped millions to lose weight. But once they're stopped, people tend to regain most of what they shed. What does this mean for their long-term health?

The same trend was seen after the 2021 trial, known as Step 1. After 68 weeks of semaglutide injections, the average patient lost more than 15% of their body weight, but within 12 months of treatment ending, patients. This was associated with a similar level of reversion to the patients' original baselines in some markers of their cardiometabolic health – a category which includes conditions such as diabetes and heart attacks.

"People don't always appreciate this," says Rubino. "I try to explain that these are chronic medications, but I think everybody secretly feels, 'Yeah, but you know what, I'm different, and once I hit my weight goal, I'll be ok.' But the reality is, the brain is quite powerful." Miras says that many people who regain weight after medication or dieting experience a change in their body composition which could potentially be even worse for their long-term health than if they had simply maintained their existing weight.

Rubino says that some people can regain weight after quitting semaglutide, but still retain some of the metabolic health benefits achieved while taking the drug, such as improved"That person may be able to be more active after losing the weight, perhaps they're sleeping better and having fewer sleep apnea events of women with polycystic ovary syndrome and obesity treated them with semaglutide injections for 16 weeks, in addition to the diabetes drug Metformin.

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