without any high-risk factors, postoperative radiotherapy alone yields similar outcomes as concurrent chemoradiotherapy, regardless of histological subtype, but chemoradiotherapy came with more grade 3 or higher hematological toxicities, new research showed.The optimal postoperative treatment regimen for patients with early-stage cervical cancer without high-risk factors remains unclear, particularly whether postoperative chemoradiotherapy is superior to RT alone.
To investigate, researchers reviewed the medical records of 403 women with stages I-IIA cervical cancer who underwent radical surgery; 105 received postoperative RT alone; and 298 received chemoradiotherapy, with a mean follow-up of 52 months. The researchers excluded patients with high-risk factors, including positive pelvic lymph node, positive resection margin, and parametrial invasion.
The authors stratified patients into intermediate-risk and low-risk groups, with large tumors , deep stromal invasion , and lymphovascular space involvement defining the intermediate-risk group.Among intermediate-risk patients, 5-year overall survival was similar with RT alone and chemoradiotherapy ; the 5-year DFS was similar between the two groups — 94.4% with RT and 93.5% with chemoradiotherapy .
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