Groundbreaking study advances human in vitro gametogenesis for infertility treatment

May 21 2024Institute for the Advanced Study of Human Biology , Kyoto University Infertility affects approximately 1 in 6 people in their lifetime worldwide according to the World Health Organization .

Now, in a study published in Nature, researchers at the Institute for the Advanced Study of Human Biology in Kyoto University, led by Dr. Mitinori Saitou, identify robust culture conditions necessary to drive epigenetic reprogramming and germ cell differentiation into precursors of mature gametes, the mitotic pro-spermatogonia and pro-oogonia with the capacity for extensive amplification, achieving a new milestone for human IVG research.

In their new study, Saitou and colleagues conducted a cell culture-based screen to identify potential signaling molecules required to drive epigenetic reprogramming and differentiation of hPGCLCs into mitotic pro-spermatogonia and oogonia. Surprisingly, the authors found that the well-established developmental signaling molecule, bone morphogenetic protein , played a crucial role in this reprogramming and differentiation process of hPGCLCs.

The authors also revealed the potential mechanisms of how BMP signaling may be leading to epigenetic reprogramming and hPGCLC differentiation. "BMP appears to be attenuating the MAPK/ERK signaling pathway and both the de novo and maintenance activities of DNMT , but further investigation will be necessary to determine the precise mechanism and whether this is direct or indirect", explains Saitou.

Health Health Latest News, Health Health Headlines

Similar News:You can also read news stories similar to this one that we have collected from other news sources.

Q&A: To protect human health, we must protect the Earth's healthHuman activities have transformed and degraded Earth's natural systems. But it's not just the planet that endures the harms of things like pollution and climate change. Changes like rising ocean temperatures and CO2 levels have cascading effects that threaten the future of humans.
Source: medical_xpress - 🏆 101. / 51 Read more »

Join the Community Mental Health Team in Belfast Health and Social Care TrustThe closing date for applications is Tuesday 21st May 2024
Source: BelfastLive - 🏆 16. / 77 Read more »

PhRMA Foundation awards grants to fight health disparities with digital health toolsThe PhRMA Foundation (PhF) awarded $500,000 grants to David G. Armstrong, DPM, MD, PhD, of the University of Southern California and Nino Isakadze, MD, MHS, of Johns Hopkins University to conduct research using digital health technologies (DHTs) to improve health equity and health outcomes for patients.
Source: NewsMedical - 🏆 19. / 71 Read more »

Exercise programs benefit a wide range of long-term health conditions, finds health data analysisA new study looking at health data from the last 20 years has highlighted the benefits of exercise programs for individuals living with long-term health conditions.
Source: medical_xpress - 🏆 101. / 51 Read more »

Americans perceive mental health treatment as inferior to physical health care, survey revealsThree-quarters of Americans feel mental health conditions are identified and treated much worse than physical health issues within the U.S.
Source: NewsMedical - 🏆 19. / 71 Read more »

Mental health first-aid training may enhance mental health support in prison settingsAccording to Rutgers Health researchers, training correctional officers in Mental Health First Aid (MHFA) for adults, a 7.
Source: medical_xpress - 🏆 101. / 51 Read more »