Could FLiRT Variants Cause Another Covid-19 Surge?

In early March of this year, a new Covid-19 variant—known as KP.2 or FLiRT—began to emerge in the United States. At that time, KP.2 represented only 0.4% of all SARS-CoV-2 strains being sequenced, but has skyrocketed in the last two months to become thestrain of the virus, making up 28.2% of sequences as of May 11. This dramatic rise signals that KP.2 has properties that promote viral transmission, and has experts discussing whether another Covid-19 surge is on the horizon.

The KP.2 variant possesses several mutations in the spike gene, which results in a protein being produced that may not be recognized by antibodies from prior infection or vaccination. So if it’s been greater than 6 months since your last vaccination or infection, it’s unlikely you’re fully protected. Existing antibodies may prevent severe disease, but may not prevent infection and subsequent mild- to moderate-illness.

As we have observed since 2020, the virus causing Covid-19 continues to evolve. Continued vigilance to reduce transmission is needed, including staying home when you are feeling sick, getting tested for Covid-19 and other common respiratory viruses , wearing a mask if you have symptoms and must go out in public, and most importantly, getting an updated Covid-19 vaccine. Taking these steps will reduce the chances of a future Covid-19 surge, and help keep you and others safe and healthy.

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