Researchers at the Netherlands Cancer Institute have discovered a new mechanism of cancer cell death involving the Schlafen11 gene, which could revolutionize the understanding and treatment of cancer. This gene helps shut down protein production in response to DNA damage, offering a new target for cancer therapies, especially in cases where traditional p53 protein pathways are ineffective. Credit: SciTechDaily.
Chemotherapy kills cancer cells. But the way these cells die appears to be different than previously understood. Researchers from the Netherlands Cancer Institute, led by Thijn Brummelkamp, have uncovered a completely new way in which cancer cells die: due to the Schlafen11 gene. “This is a very unexpected finding. Cancer patients have been treated with chemotherapy for almost a century, but this route to cell death has never been observed before.
His research group then discovered, together with the group of colleague Reuven Agami, a previously unknown way in which cells die after DNA damage. In the lab, they administered chemotherapy to cells in which they carefully modified the DNA. Thijn: “We were looking for a genetic change that would allow cells to survive chemotherapy. Our group has a lot of experience in selectively disabling genes, which we could perfectly apply here.
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