New study sheds light on interferon combinations' role in lupus variability

May 14 2024Johns Hopkins Medicine The team says this is a crucial step forward in understanding biological mechanisms behind lupus, and may also lead to shifts in how clinicians treat patients with the condition.

He says this research began with questions about why certain lupus treatments were ineffective for some patients. "We have seen instances where the patient surprisingly didn't improve -; we wondered if certain interferon groups were involved." Researchers were able to use these findings to also make several associations between these interferon combinations and lupus symptoms. In those with elevated interferon I, lupus was mainly associated with symptoms affecting the skin, such as rashes or sores. Participants with elevated levels of interferon I, II and III exhibited the most severe presentations of lupus, often with significant damage to organ systems, such as the kidneys.

Eduardo Gómez-Bañuelos, M.D., Ph.D., rheumatologist, assistant professor of medicine, Johns Hopkins University School of Medicine and study's first and additional corresponding author

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