May 14 2024Allen Institute With pediatric inflammatory bowel disease diagnoses on the rise globally, a clinical trial in Seattle aims to transform treatment approaches through deep molecular profiling.
IBD is a very complex disease, and we only have a rough understanding of what is happening at a molecular level. By partnering with the Allen Institute, we want to get a detailed view of the disease's molecular mechanisms to find better ways of treating the patients we see in the clinic." In children, IBD is both more aggressive and harder to treat. Around 30% of pediatric IBD patients do not respond to initial treatments. Furthermore, nearly half of the remaining patients will find their treatments becoming ineffective over time. These children face risks like impaired growth, mental health issues, and missed educational and social activities.
A deep dive into the molecular workings of the disease could also uncover unknown pathways of inflammation. These pathways could potentially serve as targets for the development of new drugs. "There is a universe of information that is not being seen," said Adam Savage, Ph.D., an Assistant Investigator at the Allen Institute for Immunology.
We have summarized this news so that you can read it quickly. If you are interested in the news, you can read the full text here. Read more:
Health Health Latest News, Health Health Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Study identifies risk factors for extraintestinal manifestations of IBDCertain demographic, clinical, and genetic factors heighten the risk for extraintestinal manifestations (EIMs) with inflammatory bowel disease (IBD), according to a study published online March 13 in Gastroenterology.
Source: medical_xpress - 🏆 101. / 51 Read more »
Innovative testing protocol reduces the lengthy wait for IBD diagnosisPatients with suspected inflammatory bowel disease (IBD) could benefit from better testing protocols that would reduce the need and lengthy wait for potentially unnecessary colonoscopies, a new study has found.
Source: NewsMedical - 🏆 19. / 71 Read more »
Unraveling the genetic connection between IBD and Parkinson's diseaseResearchers at the Icahn School of Medicine at Mount Sinai have made a significant discovery, identifying genetic connections between inflammatory bowel disease (IBD) and Parkinson's disease (PD).
Source: NewsMedical - 🏆 19. / 71 Read more »
Clinical trial shows CRISPR gene editing has exciting potential to treat a rare form of blindnessA recent study published in The New England Journal of Medicine investigated the potential use of gene editing to correct a congenital retinal degeneration called CEP290 that causes early-onset vision loss.
Source: NewsMedical - 🏆 19. / 71 Read more »
Clinical trial shows liver patients see benefits after going meatless for one mealJust one meal without meat can lower levels of harmful ammonia in people with advanced liver disease, researchers from Virginia Commonwealth University's School of Medicine and Richmond VA Medical Center report.
Source: medical_xpress - 🏆 101. / 51 Read more »
CRIPSR gene editing leads to improvements in vision for people with inherited blindness, clinical trial showsResults from a clinical trial of CRISPR gene editing in 14 individuals with a form of inherited blindness show that the treatment is safe and led to measurable improvements in 11 of the participants treated. The Phase I/II trial called BRILLIANCE, was led by principal investigator Eric Pierce, MD, Ph.D.
Source: medical_xpress - 🏆 101. / 51 Read more »