May 7 2024Wayne State University
The cornea, located at the front of the eye, is our focus. We aim to understand why diabetic patients are more suspectable to keratitis, or corneal infection. Why does the disease progress faster in these patients, and why are they more resistant to treatments? Diabetic patients are about 30% more likely to experience corneal infections."
Yu's research group uses mouse models of both type 1 and type 2 diabetes, along with Pseudomonas aeruginosa as a model pathogen. In May 2023, the Centers for Disease Control and Prevention confirmed 81 cases of a drug-resistant Pseudomonas aeruginosa strain across 18 states, resulting in four deaths, 14 cases of vision loss and four cases of enucleation.
Related Stories"We found evidence that mice are more susceptible to corneal infections," said Yu. "Our approach involves analyzing samples from the mice's infected corneas with similar severity. We look at the RNA sequences in the samples and compare the progression of the infection and identify the pathways, or biological processes. By comparing normal pathways to diabetic pathways, we can explore potential treatment avenues.
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