Specific class of drugs can reverse diet-induced obesity, fatty liver and diabetes in mice

Apr 30 2024Karolinska Institutet Researchers at Karolinska Institutet may have found a new way to treat obesity and related disorders by targeting the cells' powerhouses, the mitochondria. A study published in Nature Metabolism shows that a specific class of drugs that block mitochondrial function can reverse diet-induced obesity, fatty liver and diabetes in mice.

Increased fat metabolism Professor Nils-Göran Larsson's research group at Karolinska Institutet in Sweden has recently developed highly specific drug candidates that block mitochondrial function, and thus cellular energy production, to treat cancer. Now the researchers have shown that these drugs also have a beneficial effect on metabolism in mice.

Taolin Yuan, postdoctoral researcher at the Department of Medical Biochemistry and Biophysics, Karolinska Institutet

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New drug candidate reverses obesity in miceResearchers at Karolinska Institutet may have found a new way to treat obesity and related disorders by targeting the cells' mitochondria. A study published in Nature Metabolism shows that a specific class of drugs that block mitochondrial function can reverse diet-induced obesity, fatty liver and diabetes in mice.
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