Genetic associations of key genes in breast cancer pathogenesis

Apr 29 2024Xia & He Publishing Inc. Background and objectives This study aimed to elucidate the genetic associations of seven pivotal genes with breast cancer and discern their potential role in disease prognosis.

Methods The genes VEGFA, BRCA1, RAD51, CCNB1, CHEK1, CDK1, and XRCC4 were curated from over 30 articles. Their association with breast cancer was analyzed using both in silico and in vitro techniques. The in silico assessment involved constructing a protein-protein interaction network, accompanied by Gene Ontology and pathway enrichment analysis. Further, survival and expression analysis were conducted using Kaplan-Meier Plotter and the UALCAN database respectively.

Results The study revealed that all seven genes are significantly upregulated in breast cancer tissues compared to normal tissues, highlighting their critical role in tumor development and progression. Protein-protein interaction analysis confirmed their central involvement in vital biological processes related to breast cancer.

Conclusions This study contributes to the understanding of the genetic landscape of BC and underscores the potential of seven genes studied as targets for therapeutic intervention. The findings emphasize the importance of these genes in the pathology of BC and pave the way for personalized medicine. Future research should focus on exploring the therapeutic potential of these genes and developing targeted therapies for BC.

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