By Priyanjana Pramanik, MSc.Apr 21 2024Reviewed by Benedette Cuffari, M.Sc. In a recent study published in the journal Nutrients, researchers compare the efficacy between traditional and commercial Doenjang in alleviating menopausal syndrome.
Soy consumption, especially in Asian countries, is associated with lower rates of menopausal symptoms, thereby offering a natural substitute for HRT when it may be contraindicated or otherwise undesirable due to possible side effects such as breast cancer or cardiovascular disease. The Kupperman index is a widely accepted diagnostic tool for menopausal syndrome that measures a wide range of vasomotor, urinary tract, psychoneurological, motor, digestive, and systemic symptoms. Scores below 20 indicate mild symptoms, while those between 20 and 40 signify moderate severity. Scores exceeding 40 indicate severe symptoms and scores of 60 or more denote a particularly severe manifestation of the syndrome.
Safety assessments included blood chemistry, hematological tests, and monitoring for side effects. Obesity indicators and inflammation markers were also assessed, as were changes in the gut microbiome analyzed through stool tests. Safety assessments indicated no adverse effects on liver or kidney function, with some improvements in blood urea nitrogen , uric acid, and total protein levels in the HDC group. Doenjang was not associated with anti-obesity effects; however, its use reduced LDL cholesterol levels.
Conclusions Traditional Doenjang fermented with beneficial microorganisms was found to be superior in its ability to mitigate menopausal symptoms as compared to commercial Doenjang. Nevertheless, a significant reduction in Kupperman index scores was observed across all groups, with the most notable improvement observed in LDC recipients.
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