Unraveling the mysteries of gastro-esophageal junction development

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Barrett's Esophagus,Cancer,Cell

The transition from the esophagus to the stomach is a delicate region from a medical point of view, often associated with pathological disorders leading to cancer.

Apr 13 2024Julius-Maximilians-Universität Würzburg, JMU An international research team has now gained new insights into this region. These pave the way for new prevention and treatment options.

New insights into the development of the gastrointestinal tract Their results reveal the complex communication at the cellular level and the specific pathways that these cells use to communicate. They provide new insights into the development of the gastro-esophageal junction and thus have significant implications for the understanding, prevention and treatment of gastrointestinal diseases.

She herself has many years of experience in research with organoids. Among other things, she has used mini-organs she developed to study how cells in the cervix degenerate and turn cancerous - another region where different types of mucosal cells collide. Related StoriesHowever, it is still unclear why this region is so susceptible to this process. In order to better understand this transformation, it is therefore first necessary to decipher the normal development process in detail - from embryo to mature adult. "This is the only way to determine the tissue changes that trigger the progression of the disease, explains Dr. Rajendra Kumar Gurumurthy, another researcher of the study.

 

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