I find it difficult to believe that the shrinking of organs, and effects like bone loss, are either “safe” or “irreversible.” Tweaking hormonal biochemistry in someone’s body on that scale is likely to affect blood pressure, sleep patterns, weight, and many other impacts.
Instead, researchers say puberty blockers hurt the development of testicles and sperm production in ways that are not fully reversible and could affect users’ ability to have children when they grow up.In the case of one 12-year-old boy who was treated with puberty blockers for 14 months, nearly 60% of his sex glands became “fully atrophied,” and small clusters of calcium formed in his testicles, according to the study.
The study has not yet been peer-reviewed, and was published on Cold Spring Harbor Laboratory’s BioRxiv. BioRxiv sees two-thirds of its papers later published in peer-reviewed journals.
….ombined with the noted gland atrophy and abnormalities from the histology data raise a potential concern regarding the complete ’reversibility’ and reproductive fitness of SSC . The biorepository, data, and research approach presented in this study provide unique opportunity to explore the impact of PB on testicular reproductive health.