Does IBD affect cancer risk?

By Pooja Toshniwal PahariaApr 3 2024Reviewed by Benedette Cuffari, M.Sc. In a recent study published in BMC Medicine, researchers explore the causal associations between inflammatory bowel disease and cancer incidence.

IBD, including ulcerative colitis and Crohn's disease , is a chronic and progressive gastrointestinal disease that is more frequently associated with certain cancer risks. However, these findings have been contradictory and are potentially influenced by reverse causation and confounding factors. The possible causal links between IBD and cancer incidence remain poorly understood.

The researchers eliminated single-nucleotide polymorphisms associated with confounding factors like waist circumference, hip circumference, body mass index , waist-hip ratio, percentage of body fat, alcohol consumption, smoking, depression, insomnia, and physical exercise in the multivariate MR analysis to identify significant MR findings.

Related StoriesData were primarily obtained for Europeans from the United Kingdom Biobank, Kaiser Permanente Genetic Epidemiology Research on Adult Health and Aging Groups, the Transdisciplinary Research into Cancer of the Lung of the International Lung Cancer Consortia meta-analysis, and a multiple-trait genetic assessment of over 300,000 European, Australian, and American individuals.

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