Mutation Helps Even Carriers of 'Alzheimer's Gene' Avoid Alzheimer's

The protective mutation causes cells to produce a more powerful version of humanin, a tiny protein that plays an important role in cellular function.

“This new study sheds light on resilience genes that help people live longer and partially explains why some people at high risk for developing Alzheimer's Brain function tests among centenarians with the APOE4 gene found that those who also carried the PS3-humanin gene outperformed those who didn't, suggesting that the humanin variant blunted some of their Alzheimer's risk.

Treatment with standard humanin protein also resulted in some decrease of amyloid beta, but the effect was more powerful with the genetic variant, researchers said.Analysis showed that PS3-derived humanin allows it to bind more effectively with the APOE4 gene, researchers said.

Health Health Latest News, Health Health Headlines

Similar News:You can also read news stories similar to this one that we have collected from other news sources.

This Mutation Likely Saved a Colon Cancer Patient's LifeHis tumor had a specific genetic makeup known as mismatch repair-deficient, present in 5% to 10% of all rectal cancer patients, meaning he might qualify for a cutting-edge immunotherapy.
Source: WebMD - 🏆 709. / 51 Read more »