High-intensity exercise could reverse Parkinson’s disease-related neurodegeneration by improving dopamine-producing neurons’ health, a pioneering study suggests, offering new hope for managing the disease through physical activity. Credit: SciTechDaily.com
In fact, after six months of exercise, the neurons actually had grown healthier and produced stronger dopamine signals. Dopamine is a chemical that helps brain cells communicate with each other. The researchers recently published their findings in“This is the first time imaging has been used to confirm that the biology of the brain in those suffering with Parkinson’s disease is changed by intense exercise,” says Evan D. Morris, Ph.D.
The most common available medication, levodopa, replaces the missing dopamine. While the drug is effective in alleviating motor symptoms, it does not prevent the ongoing neurodegeneration and can cause undesirable side effects with long-term use such as uncontrolled excessive movements . There is currently no cure for the disease.Exercise is an essential component of Parkinson’s disease management. In fact, some gyms offer exercise programs specifically for the condition.
After the trial period, the participants received their first round of brain scans. One was an MRI scan that measured the amount of neuromelanin—a dark pigment found in dopamine-producing neurons—in the substantia nigra. The second scan was a PET scan that measured dopamine transporter availability. DAT is a protein that helps the neurons maintain proper dopamine levels.pandemic, the classes took place online.