Stopping HIV in Its Tracks: New Anti-Viral Treatment Hacks the Virus’ Protective Shield

Lenacapavir, an innovative anti-retroviral drug, thwarts HIV replication by destabilizing its protective capsid, with research from UNSW Sydney providing crucial insights into its mechanism and potential for further antiviral developments.

“What we found was that this hyper-stabilization actually led to a premature breakage of the capsid, before the virus can finish converting its RNA into DNA,” Professor Böcking said. “With our microscope setup, we can look at the integrity of the capsids. By monitoring the release of fluorescent tags loaded into the capsid, we can work out exactly when it cracks,” said Dr Walsh, one of the study’s lead authors.

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