Researchers develop a risk prediction model for cisplatin-induced kidney damage

Mar 27 2024Brigham and Women's Hospital

Patients receiving treatment for cancer are increasingly affected by kidney injury, which is associated with higher mortality and can jeopardize eligibility for other therapies. Cisplatin is a well-known kidney toxin, and even though there are newer treatments available, it remains a cornerstone of therapy for patients with cancer globally. This large, multicenter collaboration and resulting risk prediction model is an important step in the care of patients who are getting cisplatin.

The researchers examined data from over 24,000 patients across six major U.S. cancer centers, including Dana-Farber Brigham Cancer Center, Mass General Cancer Center, Memorial Sloan Kettering Cancer Center, MD Anderson Cancer Center, University of Colorado, and Northwell Health, and analyzed the risk of moderate-to-severe acute kidney injury within the first 14 days following a single, first IV dose of cisplatin.

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