Following the “disappointing” announcement that two late-stage trials for a promising treatment for Alzheimer’s disease had been cancelled, a Toronto behavioural neurologist studying the drug says there’s still reason for hope.
Dr. Sharon Cohen, a behavioural neurologist and medical director of the Toronto Memory Program who is the lead investigator in Canada for the drug, described aducanumab as an antibody that is shown to remove beta-amyloid plaque from the brains of individuals with early Alzheimer’s disease. “[It] was to provide further evidence, not that we’re reducing amyloid plaque, we know we can do that with aducanumab, but that actually people are better off. Their disease is halted or slowed down,” Cohen told CTV News Channel on Wednesday.
Cohen said there are several hypotheses as to why the clinical trials didn’t produce the results they wanted. She said it’s possible the subjects in the trials had more advanced Alzheimer’s disease than they thought and there was already too much damage from amyloid plaque when they were given aducanumab.
The behavioural neurologist said perhaps amyloid plaque needs to be treated at an earlier stage while tau is tackled at a more advanced stage in the disease’s progression.
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