Mar 22 2024University of Toronto Researchers at the University of Toronto and Sinai Health have created a new platform to identify proteins that can be co-opted to control the stability of other proteins -; a new but largely unrealized approach to the treatment of disease.
Juline Poirson, first author on the study and visiting scientist at U of T's Donnelly Centre for Cellular and Biomolecular Research The effectors currently in use for targeted protein degradation and stabilization are E3 ubiquitin-ligases and deubiquitinases , respectively. E3 is an enzyme that transfers the ubiquitin molecule to the target protein, which essentially flags the protein for a proteosome to digest it. On the other hand, a DUB enzyme removes the ubiquitin tag from a protein, thereby preventing the protein from being recognized and degraded by a proteosome.
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