Mar 21 2024Universidad Carlos III de Madrid - Oficina de Información Científica Scientists from Universidad Carlos III de Madrid and Johns Hopkins University , in the USA, have analyzed the growth of breast tumors from a biomechanical perspective and have created a computational model that simulates the invasion process of cancer cells, depending on the characteristics of the surrounding tissue and cell junctions, among other parameters.
In this model we have simulated how breast tumor cells invade the surrounding tissue, and how they proliferate more or less depending on how stiff and porous the surrounding tissue is or how strong the cell junctions with other cells are." To do this, the researchers have worked with spheroids to simulate how cells behave in a real tumor under different mechanical conditions. These spheroids consist of groups of tumor cells embedded in a fibrillar matrix whose characteristics can be modulated.
"While experimentally, proliferation and invasion are often measured as two independent parameters, we observed a strong coupling of these processes. Although they could not be isolated using traditional experimental outputs, the computational model allowed us to study these processes independently and gather insights from the biomechanical properties of our system", adds another of the JHU team's researchers, Ashleigh Crawford.
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