Concomitant pharmacotherapy overcomes immunotherapy challenges in aggressive blood cancer

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Researchers at the University of Zurich and the University Hospital Zurich have discovered that a specific mutation in the cancer cells of an aggressive type of blood cancer can prevent novel immunotherapies such as CAR T-cell therapy from working.

Mar 21 2024University of Zurich Their study also explains why the cancer cells are resistant and how this resistance can be overcome: through concomitant pharmacotherapy or genetically improved CAR T-cells.

Mutation in blood cancer cells weakens immunotherapy defense cells An international research team led by Professors Markus Manz and Steffen Boettcher from the University of Zurich and the Department of Medical Oncology and Hematology at the University Hospital Zurich has now shown that TP53-mutant AML cells are also significantly more resistant to a new type of immunotherapy - CAR T-cell therapy - than AML cells without the mutated gene.

 

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