Workout in a pill: Scientists move one step closer to an exercise-mimicking drug

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Nicoletta Lanese is the health channel editor at Live Science and was previously a news editor and staff writer at the site. She holds a graduate certificate in science communication from UC Santa Cruz and degrees in neuroscience and dance from the University of Florida.

Could popping a pill bring someone similar benefits to running on a treadmill or doing resistance training? In new research, scientists moved one step closer to making this a reality and developing a drug that can mimic some of the cellular effects of exercise.

Broadly, it's intended for those who face major physical barriers to exercising."We're hoping that this can help all of these cases," said Elgendy, who's also the co-founder of Pelagos Pharmaceuticals, a startup aimed at developing these exercise-mimicking drugs, or so-called exercise mimetics. By submitting your information you agree to the Terms & Conditions and Privacy Policy and are aged 16 or over."This is an early-stage drug discovery program; it's not complete yet," Elgendy said."If everything goes well, we're hoping in the next couple of years."

ERRs come in three flavors — alpha, beta and gamma — and in the past, scientists had found ways of activating the beta and gamma receptors with human-made compounds. But alpha, known to be very prevalent in the brain and in skeletal muscle, proved difficult to target.

 

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