New compounds show potential to mimic benefits of exercise

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Doctors have long prescribed exercise to improve and protect health. In the future, a pill may offer some of the same benefits as exercise.

Mar 18 2024American Chemical Society Now, researchers report on new compounds that appear capable of mimicking the physical boost of working out -; at least within rodent cells. This discovery could lead to a new way to treat muscle atrophy and other medical conditions in people, including heart failure and neurodegenerative disease.

Exercise benefits both mind and body. In this case, Elgendy, a professor of anesthesiology at Washington University School of Medicine in St. Louis, and his colleagues are hoping to recapitulate its potent physical effects -; namely, exercise's ability to enhance muscle cells' metabolism and growth, along with improved muscle performance.

To identify SLU-PP-332, the researchers scrutinized the structure of the ERRs and how they bind to molecules that activate them. Then, to improve upon their discovery and develop variations that could be patented, Elgendy and his team designed new molecules to strengthen the interaction with the receptors and thus provoke a stronger response than what SLU-PP-332 can provide.

 

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