Two early trials published Wednesday showed promise in treating one of the deadliest types of cancer, glioblastoma. The aggressive brain cancer, which took the lives of John McCain and Beau Biden, is only diagnosed at stage 4, and the five-year survival rate is around 10%. The disease has no cure and, according to Dr.
To further prevent the CAR-T cells from escaping, the researchers bulked them up by binding them to an antibody, which made it more difficult for the cells to cross the blood-brain barrier and enter the bloodstream. All three patients — two who were in their 70s and one in her late 50s — responded quickly to the treatment. Brain scans showed their tumors shrunk significantly within a day of receiving the therapy.
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