Novel dual-target CAR T cell therapy shows promise in treating recurrent glioblastoma

Mar 13 2024University of Pennsylvania School of Medicine Targeting two brain tumor-associated proteins-; rather than one-; with CAR T cell therapy shows promise as a strategy for reducing solid tumor growth in patients with recurrent glioblastoma , an aggressive form of brain cancer, according to early results from the first six patients treated in an ongoing Phase I clinical trial led by researchers from the Perelman School of Medicine at the University of Pennsylvania and Penn Medicine's...

GBM is the most common-;and most aggressive-;type of cancerous brain tumor in adults. Individuals with GBM usually expect to live 12-18 months following their diagnosis. Despite decades of research, there is no known cure for GBM, and approved treatments-;such as surgery, radiation, and chemotherapy-;have limited effect in prolonging an individual's life expectancy. However, even after aggressive treatment, GBM returns in most patients, which is known as recurrent GBM.

In this trial, researchers used a technology developed in the lab of Donald M. O'Rourke, MD, the John Templeton, Jr., MD Professor in Neurosurgery and director of the Glioblastoma Translational Center of Excellence at the Abramson Cancer Center, and scientific advisor to the trial.

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