Light and sound may slow Alzheimer’s by making the brain remove toxins

A new explanation has emerged for why an experimental treatment for Alzheimer’s disease involving sounds and flickering lights may help slow cognitive decline.

As it was known that visual or auditory stimulation at a certain frequency can boost brainwaves at that same frequency, in 2016, Tsai’s team decided to investigate if 40 Hz stimulation might boost cognitive abilities in people with Alzheimer’s.Their group and others showed that this lowered amyloid build-up in mice with a version of Alzheimer’s and had cognitive benefits in, with a larger trial ongoing.

In the latest work, Tsai’s team carried out a series of experiments to study the treatment’s mechanism in mice that had been genetically altered so that they usually develop a build-up of amyloid as they get older and have worse memories than typical mice.

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