Gender variations in brain aging among Parkinson's Disease patients

By Vijay Kumar MalesuFeb 16 2024Reviewed by Lily Ramsey, LLM In a recent study published in npj Parkinson’s Disease, researchers explored how sex influences brain aging in Parkinson's disease by analyzing Magnetic Resonance Imaging -derived brain age differences and their clinical correlations.

Studies reveal sex differences in PD's clinical presentation, with men more prone to cognitive impairments and women exhibiting milder symptoms. With a mean age of 49.15 years and a slight female majority, the model was developed to gauge brain age across different groups accurately. The brain age estimation was executed through support vector regression, considering factors like sex, scanner attributes, and total brain volumes.

These models were applied separately for male and female patients to detect sex-specific associations. The study highlighted that while overall motor symptom severity did not significantly vary between sexes, rigidity was more pronounced in males. A core component of the study was the assessment of brain age through a machine learning model, which showed a higher Brain-PAD in PD patients compared to healthy controls, signifying accelerated aging in PD.

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