By Dr. Chinta SidharthanNov 8 2023Reviewed by Susha Cheriyedath, M.Sc. In a recent study published in the journal Molecular Psychiatry, a team of researchers conducted a large-scale meta-analysis consisting of an epigenome-wide association study to understand whether lifetime use of cannabis was linked to deoxyribonucleic acid methylation observed in peripheral blood.
DNA methylation is an indicator of the impact of environmental factors on health, and some forms of DNA methylation due to environmental factors are long-lasting, while others are transient. It occurs when a methyl group gets added to the fifth carbon of cytosine in regions with cytosine and guanine repeats. Studies have reported that cigarette smoking results in both persistent and transient DNA methylation at CpG sites across the genome.
DNA methylation was measured in the peripheral blood samples, and the β-values, which is the percentage of methylated DNA at the targeted CpG sites, were calculated. The association between lifetime cannabis use and DNA methylation levels was tested using linear models or a generalized estimating equations model in cohorts where the participants were related.
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