Benefits of Tebentafusp in Uveal Melanoma Last 3 Years

Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit.in the IMCgp100-202 study lasted through at least 36 months of follow-up. After 3 years, 27% of patients in the tebentafusp group had survived, compared with 18% in the control group.

Tebentafusp is the first T-cell receptor, bispecific fusion protein that triggers T cells to target gp100-positive melanoma cells. Tebentafusp is the only approved systemic therapy for adult HLA-A*02:01-positive patients with unresectable or metastatic uveal melanoma.

The OS for the 99 patients in whom the ctDNA level decreased by at least 50% was longer than for the 24 patients in whom it decreased by less than 50%, did not change, or increased."The role of ctDNA as an indicator for the initial benefit, which is overlooked by RECIST, cannot be overstated here," said Hamid.

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