Study: Topical application of synthetic melanin promotes tissue repair. Image Credit: Aleksey Boyko / Shutterstock.com
Oxidative stress is a major cause of poor skin healing and arises due to excess ROS. At low levels, ROS inhibits potentially pathogenic bacteria and enhances regenerative signaling pathways. However, when ROS overwhelms the antioxidant capacity of the tissue, cell damage arises as a result of disrupted molecular pathways, thereby causing inflammation.
Related StoriesResearchers used two synthetic melanin particles , which are nanoparticles with low and high surface areas . The supposition is that SMPHi would be a better scavenger, thereby resulting in better wound healing. SMPHi had higher free radical scavenging activity at lower concentrations; however, both particle types plateaued at the same concentration of about 100 μg. SMPs matched or exceeded other antioxidants in their scavenging capability.
SMP application was accompanied by the restoration of skin SOD activity, which showed a marked reduction after NM-induced injury. This was more obvious in the SMPHi group. Other antioxidant enzymes, like catalase, were unaffected.
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Source: NewsMedical - 🏆 19. / 71 Read more »
Source: NewsMedical - 🏆 19. / 71 Read more »