The most lethal aspect of any cancer is metastasis, which is the spread of cancer cells throughout the body. Groundbreaking research led byhas uncovered for the first time the mechanisms that may enable breast cancer cells to invade healthy tissues.
The researchers used live microscopy to watch the migration of live breast cancer cells in two different systems modeled after the human body. The first system, a two-dimensional network of collagen fibers, revealed how cancer cells move through an extracellular matrix that surrounds tumors and showed that dynein was key to the movement of cancer cells.
A human breast cancer cell, adenocarcinoma MDA-MB-231, demonstrates metastatic-like adhesion, spreading and migrating in a collagen matrix designed to mimic soft tissue. New research led by Penn State reveals for the first time the mechanics behind how breast cancer cells may invade healthy tissues.
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