A major goal of the laboratory is to develop novel therapeutics to target alterations in the estrogen receptor to restore hormone sensitivity, as well as identify other novel mechanisms of resistance. The Staff Scientist will have experience with various molecular biology techniques such as ChIP-PCR, IP, qRT-PCR, western blotting, FACS, organoids, cell culture and other lab techniques. We offer opportunities to conduct wet-lab and dry-lab approaches within the lab.
Define the molecular mechanisms underlying the hypersensitive ER mutant phenotype by studying the association of mutant vs. wild-type ER alpha with critical co-activators and co-repressors, the dynamics of mutant vs. wild-type ER/co-regulator complexes on specific promoter DNAs, using ChIP and co-immunoprecipitation assays, ubiquitin-mediated degradation, and protein acetylation PDF.
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