Reviewed by Danielle Ellis, B.Sc.Oct 31 2023 We are embarking on an unprecedented era of therapeutic development enabled by live cell
engineering. Genetic engineering of cells goes beyond a simplistic ́ ́hit-and-kill ́ ́ approach using synthetic biology to enable smart decisions that allows transgenic cells to react in response to systemicresponses.targeting transformed cells are key unmet needs in designing cell therapies for patients with solid
cancer. Innovative solutions include the possibility to rewire decision making of transgenic cells in regard to quality and strength of contextual immune effectorfunctions as well as epigenetic programming.entities and calls for cross-fertilizing cooperation.
Dr. George Coukos | Dir. Ludwig Institute for Cancer Research and Dept of Oncology, UNIL-CH Lausanne, CHDr. Sergio Quezada | Pof Cancer Immunology and Immunotherapy, UCL, London, UK and Achilles
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