Two 'big gun' antibiotics may be safer for the kidneys than previously thought

Reviewed by Megan Craig, M.Sc.Oct 16 2023 Two 'big gun' antibiotics thought to cause kidney failure in ICU patients with a severe bacterial infection, especially when combined with another antibiotic, may be safer for the kidneys than previously reported, following a randomized trial led by Vanderbilt University Medical Center .

The Antibiotic Choice on Renal Outcomes randomized clinical trial compared cefepime vs. piperacillin/tazobactam in adults prescribed one of these antibiotics within 12 hours of presenting to the emergency department or medical intensive care unit at an academic medical center in the U.S. between Nov. 10, 2021 and Oct. 7, 2022.

Related StoriesAs a secondary outcome, authors reported that treatment with cefepime resulted in more neurological dysfunction, with patients in that group experiencing fewer days alive and free of delirium and coma within 14 days in the piperacillin/tazobactam group.

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ICU antibiotics may be safe for kidneys, says clinical trialTwo 'big gun' antibiotics thought to cause kidney failure in ICU patients with a severe bacterial infection, especially when combined with another antibiotic, may be safer for the kidneys than previously reported, following a randomized trial led by Vanderbilt University Medical Center (VUMC).
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