Drug used in diabetes treatment Mounjaro helped dieters shed 60 pounds, study finds

By comparison, a group of people who also dieted and exercised, but then received dummy shots, lost weight initially but then regained some, researchers reported Sunday in the journal Nature Medicine.

“Any way you slice it, it's a quarter of your total body weight," said Dr. Caroline Apovian, who treats obesity at Brigham and Women's Hospital and wasn't involved in the study. Tirzepatide targets two hormones that kick in after people eat to regulate appetite and the feeling of fullness communicated between the gut and the brain. Semaglutide, the drug used in Ozempic and Wegovy, targets one of those hormones.

Participants in both groups lost about 7% of their body weight, or almost 17 pounds , during the diet-and-exercise phase. Those who received the drug went on to lose an additional 18.4% of initial body weight, or about 44 pounds more, on average. Those who received the dummy shots regained about 2.5% of their initial weight, or 6 pounds .

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