Blocking immune molecule reduces tumor growth, prolongs survival of most aggressive childhood cancer in animal models

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Researchers have confirmed that blocking an immune checkpoint molecule reduces tumor size and prolongs survival in animal models of the most aggressive childhood cancer.

This study, carried out by researchers from Cima and the Clínica Universidad de Navarra, together with the international cooperative group Diffuse Midline Glioma , shows that inhibition of TIM-3 promotes the immune memory of diffuse intrinsic stem glioma and improves the prognosis of the disease.DIPG is an aggressive brain stem tumor and the leading cause of death related to pediatric cancer. Due to its location have shown good results in various solid tumors.

"As a consequence, long-term survival of experimental models is increased. Therefore, TIM-3 is presented as a therapeutic target that can guide the development of clinical trials for these patients," say the researchers.: retrieved 11 October 2023 from https://medicalxpress.com/news/2023-10-blocking-immune-molecule-tumor-growth.html

 

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