Reviewed by Danielle Ellis, B.Sc.Oct 9 2023 SSRI antidepressants normally take a few weeks before any showing mental health benefits, but how come it takes so long? Now a study from a group of clinicians and scientists provides the first human evidence that this is due to physical changes in the brain leading to greater brain plasticity developing over the first few weeks of SSRI intake. This may also begin to explain one of the mechanisms of how antidepressants work.
Doctors have been puzzled as to why Selective Serotonin Reuptake Inhibitors take time before having an effect. Researchers in Copenhagen, Innsbruck, and University of Cambridge have undertaken a randomised, double-blind placebo-controlled study in a group of healthy volunteers which shows a gradual difference in how many nerve cell connections the brain cells have between those taking the antidepressants and a control group, depending on how long the treatment lasts.
Related StoriesThe neocortex takes up around half of the brain's volume; it is a complex brain structure that deals with higher functions, such as sensory perception, emotion, and cognition. The hippocampus, which is found deep in the brain, functions with memory and learning.
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