By Neha MathurOct 4 2023Reviewed by Danielle Ellis, B.Sc. In a recent article published in Scientific Reports, researchers conducted a population-based study with a case–control design in rural areas of Honduras in Central America to examine whether wood cookstove use by indigenous populations was associated with increased risk of stomach cancers, including gastric adenocarcinoma .
Metabolizing phase I enzymes, such as cytochrome P450 Family 1 Subfamily B Member 1 and CYP1A2, and phase II enzymes, glutathione S transferases and N-acetyltransferases modify these compounds. However, genetic variation in the genes encoding HCAs and PAHs activating/deactivating enzymes might modify the risk for GA.
Since the region has a high H. pylori prevalence, the team used a validated multiplex serology assessment to determine the participant's CagA and H. pylori infection statuses. Related StoriesWood stove use modified the rs1800440 single nucleotide polymorphism of the CYP1B1 gene independent of the CagA genotype and other GC risk factors. Thus, wood stove use increased the risk of GC by more than 2.3 times or by 40%, even after adjusting for age, sex, and CagA status. Previous studies did not find a link between the rs1800440 variant and GC and colon cancer, likely because this association was only significant in individuals exposed to wood stove use.