Unveiling the role of astrocyte-derived LCN2 in neurodegenerative disease progression

By Pooja Toshniwal PahariaOct 4 2023Reviewed by Lily Ramsey, LLM In a recent review published in Experimental & Molecular Medicine, researchers reviewed existing data on the neurodegenerative effects of astrocyte-derived lipocalin-2 .

About the review In the present review, researchers reported LCN-2 as a target for neuroprotective research. In contrast, Janus kinase/signal transducer and activator of transcription 3 activation is associated with the A2 type, promoting anti-inflammatory cytokine release, including TGF-β and IL-10, and neurotrophic factors, including vascular endothelial growth factor and brain-derived neurotrophic factor , that exert neuroprotective effects.

They perform various functions to ensure proper brain function, including structural support, modulation of neurotransmitter activity, regulation of extracellular ion balance, participation in blood-brain barrier regulation, and support of metabolic processes to support neuronal health and function.

LCN2, reactive astrogliosis, aging, and neurodegenerative disorders Reactive astrogliosis is a disorder in which astrocytes become activated, resulting in neurodegeneration and GFAP overexpression. This is related to proteostasis loss and disrupted intercellular communication, which leads to neurodegeneration and reactive astrogliosis.

LCN-2 is also involved in the neuroinflammation and neurotoxicity caused by lipopolysaccharide . Glial cell activation by inflammatory stressors, such as lipopolysaccharide administration, is comparable to neurodegenerative disorders.

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