Surprising Link Between Loneliness and Parkinson's Disease

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Is this a preventable cause of a devastating neurologic condition? Dr F. Perry Wilson comments.

Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit., your weekly dose of commentary on a new medical study. I'm Dr F. Perry Wilson of the Yale School of Medicine.— released in January and available in bookstores now — where, in chapter 11, I call attention to the problem of loneliness and its relationship to the exponential rise in deaths of despair. But Vivek, if you did, let me know.

The study examines data from just under 500,000 individuals in the UK who answered a survey including the question"Do you often feel lonely?" between 2006 and 2010; 18.4% of people answered yes. Individuals' electronic health record data were then monitored over time to see who would get a new diagnosis code consistent with Parkinson's disease. Through 2021, 2822 people did — that's just over half a percent.

Still, the costs of loneliness are not measured exclusively in Parkinson's disease, and I would argue that the real risks here come from other sources:. Nevertheless, the weak but significant association with Parkinson's disease reminds us that loneliness is a neurologic phenomenon. There is something about social connection that affects our brain in a way that is not just spiritual; it is actually biological.

The authors adjusted for all of these factors and found that, on the relative scale, lonely people were still about 20%-30% more likely to develop Parkinson's disease.

 

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