Nobel in medicine goes to scientists whose work led to mRNA vaccines against COVID

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Two scientists have won the Nobel Prize in medicine for discoveries that enabled the creation of mRNA vaccines against COVID-19 and that could be used to develop other shots in the future

FILE - Hungarian biochemist Katalin Kariko poses for a photo in Budapest, Hungary, Saturday, June 3, 2023. Two scientists have won the Nobel Prize in medicine for discoveries that enabled the development of mRNA vaccines against COVID-19. The award was given to Katalin Karikó and Drew Weissman. Karikó is a professor at Sagan’s University in Hungary and an adjunct professor at the University of Pennsylvania.

But simply injecting lab-grown mRNA into the body triggered a reaction that usually destroyed it. Karikó, a professor at Szeged University in Hungary and an adjunct professor at the University of Pennsylvania, and Weissman, of the University of Pennsylvania, figured out a tiny modification to the building blocks of RNA that made it stealthy enough to slip past those immune defenses.

“We would likely only now be coming out of the depths of COVID without the mRNA vaccines,” Hunter said. “It’s possible that we could vaccinate people against abnormal cancer proteins and have the immune system attack it after being given a targeted mRNA shot,” he explained. “It’s a much more targeted technology than has been previously available and could revolutionize how we handle not only outbreaks, but non-communicable diseases.”

While mRNA vaccines were widely used in North America and across Europe to shut down COVID-19, only a small number of the shots were made available to poorer countries months after vaccination started in rich countries.

 

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