By Susha Cheriyedath, M.Sc.Sep 26 2023 In a preclinical study published in the journal Frontiers in Pharmacology, researchers from the USA investigated the potential chemopreventive effects of a mushroom - Ganoderma lucidum -derived commercial product named GLSF in vitro and in mice with lung carcinogenesis induced by two tobacco smoke carcinogens, namely benzo[a]pyrene and 4--1--1-butanone .
A medicinal mushroom, GL is known to have anticancer and immunomodulating properties and has been employed as a nutraceutical in the treatment of various chronic ailments, including cancer. However, the effects of GL or GL-derived products have not been studied for the prevention of tobacco-smoking-induced lung carcinogenesis.
Results and discussion In the in vitro experiments, GLSF was found to inhibit the BPDE-induced transformation of BEAS-2B cells, indicating its potential role in controlling the cellular alterations resulting from the exposure of these bronchial epithelial cells to known carcinogens. The findings corroborate with existing literature.
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