Breast Cancer Drug Could Trigger Dangerous High Blood Sugar

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For certain patients with advanced breast cancer, a drug called Piqray (alpelisib) may extend survival. But new research confirms the medication often causes seriously high blood sugar levels.

Piqray blocks insulin in cells, which leads to higher circulating levels of blood sugar, Iyengar explained.can affect blood sugar levels among patients taking this medication, he said.

Alpelisib is the only U.S. Food and Drug Administration-approved PI3K inhibitor. "There are several newer mutation-specific PI3K inhibitors that are currently inwhich do not cause hyperglycemia, but it is unknown whether they are as effective,” Iyengar said. The findings confirm Piqray's effect on blood sugar, said Dr. Natalie Klar. She is a medical oncologist and assistant professor of medicine at NYU Langone“Almost all patients develop elevated blood glucose/sugar levels as well as pre-

 

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