Understanding of mechanisms behind post-exercise lack of appetite can open new paths to obesity treatment

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The complex relationship between physical activity and energy balance—food intake versus energy expenditure—is still a challenge for science, especially in light of the rising worldwide prevalence of overweight and obesity. Some of the medications available on the market to combat obesity work analogously to hormones associated with appetite control, and for some time researchers have focused on understanding how processes involving metabolites (products of cell metabolism) affect hunger and satiety.

reported in the same issue investigating the metabolic interaction between carbohydrates and exercise, and its role in acute appetite regulation.

"The most interesting point made by the article about their study is that acute exercise suppresses hunger, but hormone function is not sufficient to explain this effect," Brunetta told Agência FAPESP."Frampton and colleagues investigated the mechanisms by which exercise and dietary conditions alter metabolites, concluding that some of these, such as acetate and succinate, can be considered predictors of satiety.

Both the carbohydrate and the exercise raised blood levels of hunger-reducing hormone GLP-1 and lowered levels of ghrelin, a hormone that increases hunger.

 

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