Personalized combination treatment turns on an immunometabolic switch to effectively control aggressive prostate cancer

📆 9/18/2023 11:56 PM
📰 medical_xpress

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Researchers at the University of Chicago Medicine Comprehensive Cancer Center established 'proof-of-concept' for a new treatment approach that was able to effectively treat the most aggressive forms of prostate cancer. The treatment showed complete tumor control and long-lasting survival without side effects in a mouse model of advanced prostate cancer.

," said Akash Patnaik, MD, Ph.D., MMSc, an accomplished physician-scientist and internationally-recognized expert in prostate cancer research and treatment, who is the senior author of the publication.

Patnaik's lab develops targeted therapeutic strategies to improve the responsiveness of prostate cancer to immunotherapy. They discovered that the They then tested a therapy regimen that consisted of three drugs targeting the PI3K, MEK, and Wnt/β-catenin signaling pathways. This brought the response rate to 100%.

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