Advanced young-onset adenoma increases the risk for new colorectal cancer eightfold, according to a study published online in the September issue of theYas Casey, M.D., from the VA Loma Linda Healthcare System in California, and colleagues compared the risk for incident and fatal CRC inaged younger than 50 years with YOA diagnosis versus those with a normal colonoscopy. The analysis included 54,284 U.S. veterans who received a colonoscopy between 2005 and 2016.
The researchers found that cumulative 10-year CRC incidence was 0.11 percent after any adenoma diagnosis, 0.18 percent after advanced YOA diagnosis, 0.10 percent after nonadvanced adenoma diagnosis, and 0.06 percent after normal colonoscopy. Incident CRC risk was eightfold higher in veterans with advanced adenoma versus those with normal colonoscopy . No differences in fatal CRC risk were seen across groups.