, which were not a clear yes or no, and the team could not rule out nonspecific interactions.
While screening a library of fragments, they observed the transverse relaxation rate of the fragments, which indicates the speed at which they tumble in the solution. Astumble more slowly than small ones, an increase in a fragment's R2 value was a sign that it had interacted with a target protein. Scientists working in drug discovery still face challenges. At the moment, it is only possible to screen 1,000–2,000 fragments in one go, which limits the use of a library. Exploring a wider range of fragments at a time would make the process more efficient. The sensitivity of the NMR system is also a limiting factor, and false positives continue to be a significant issue.
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