More importantly, the research team was able to prevent the death of neurons, rescuing them in the process. The discovery opens new pathways for potential future treatments.
The study sheds light on the previously murky waters of AD, revealing a potential key player in neuronal loss, an RNA gene called MEG3, and the process of necroptosis. These findings are an important step forward in furthering our understanding of the basic mechanisms underlying this complex and often misunderstood disease.
The paper, titled"MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer's disease," is published inProfessor Bart De Strooper, group leader at UK DRI at UCL and VIB-KU Leuven Center for Brain and Disease Research, said,"Our study sheds light on the previously murky waters of Alzheimer's disease, revealing a potential key player in neuronal loss—an RNA gene called MEG3, and the process of necroptosis.
Sriram Balusu, postdoctoral researcher in the De Strooper lab and first author of the paper, said,"To bridge this gap, we created a new model, we implanted both healthy human and mouse neurons into the brains of AD mouse models. The
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